Grid: A location dependent intensity modulated radiotherapy for bulky tumors
نویسندگان
چکیده
T reatment of large and bulky malignant tumors remains a challenge for oncologists. As tumor size increases the ability of most modalities including conventional external beam radiation to control the tumor decreases. The decrease in normal tissue tolerance with increasing volume of tissue irradiated restricts the escalation of total radiation dose by conventional external beam approaches. Altered fractionation such as hyperfractionation or accelerated fractionation has been utilized in an effort to increase the dose to the tumor and enhance local tumor control. However, for advanced and bulky tumors (>8 cm), local tumor control still remains dismal even with altered dose/time fractionation approaches (Dubben et al. 1998, Johnson et al. 1995). Therapeutic options are limited and palliative measures need to be tailored to the short life expectancy of these patients. "Spatially fractionated" radiation (grid ABSTRACT
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Grid: A location dependent intensity modulated radiotherapy for bulky tumors
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